Cause of Diabetes: Low O2 in Cells Due to Heavy Breathing

What causes diabetes? On a cell level, the cause of diabetes is simple. Several medical research groups (Moritz et al, 2002; Carroll & Ashcroft, 2006; Regazzetti et al, 2009; Halberg et al, 2009; Heinis et al, 2010; Cheng et al, 2010) have recently discovered that oxygen levels in pancreatic beta-cells regulate activity of pancreatic cells through hypoxia-inducible factor 1-alpha.

Tissue hypoxia and reduced perfusion cause poor glucose and insulin control, and insulin resistance. There are many other problems caused by tissue hypoxia.

The cause of low body O2 is heavy breathing. This fact was confirmed by all 5 clinical studies that measured breathing rates in people with diabetes mellitus. Over 180 Soviet doctors developed and tested a therapy that normalizes breathing in people with diabetes (see details below).

Minute ventilation numbers explain the cause of diabetes

*One row corresponds to one research paper or medical science article

Condition	Minute ventilation	Number of patients	All references or click below for abstracts
Normal breathing	6 L/min	-	Medical textbooks
Healthy Subjects	6-7 L/min	>400	Results of 14 studies
Diabetes	12-17 L per min	26	Bottini et al, 2003
Diabetes	10-20 L per min	28	Tantucci et al, 1997
Diabetes	13 (±2) L per min	20	Tantucci et al, 1996
Diabetes	15 (±2) L per min	45	Tantucci et al, 2001
Diabetes	12 (±2) L per min	8	Mancini et al, 1999

Hence, if we consider medical facts, we can realize that all diabetics are hyperventilators (fast and deep breathers). Therefore, the Table above explains the physiological cause of diabetes.

Low cell oxygenation produces numerous adverse effects, such as oxidative stress, generation of free radicals in cells, chronic inflammation, reduced ability to heal injuries, suppression of the immune system, and many others (see links to medical studies below). The video of the left side ("Cause of diabetes") features Dr. Artour Rakhimov who explains the reasons behind low O2 in cells for people with diabetes, heart disease and asthma.

The ineffective respiratory pattern or heavy breathing in diabetes causes systemic hypocapnia (CO2 deficiency in the alveoli, arterial blood and other cells). Hypocapnia leads to vasoconstriction and the suppressed Bohr effect. As a result, hypocapnia reduces body and cell oxygenation. It can decrease insulin production (due to insufficient perfusion and oxygen supply to pancreas) or it can lead to chronic pancreatic inflammation. Furthermore, those patients who have more severe forms of hyperventilation (less than 10 s for the body O2 test) will experience more problems due to complications of type 2 diabetes.

References for Cause of Diabetes page.

Related pages:
- Diabetes Mellitus: Its causes and proven medical treatment tested by more than 180 Soviet doctors on hundreds of people with diabetes.
- Effects of Breathing Exercises on Diabetes Symptoms and Complications: Learn about the clinical effects and exact required numbers for body O2 test and pulse that lead to complete elimination of symptoms of diabetes.

Reference pages: Breathing norms and medical facts:
- Breathing norms: Parameters, graph, and description of the normal breathing pattern
- 6 breathing myths: Myths and superstitions about breathing and body oxygenation (prevalence: over 90%)
- Hyperventilation: Definitions of hyperventilation: their advantages and weak points
- Hyperventilation syndrome: Western scientific evidence about prevalence of chronic hyperventilation in patients with chronic conditions (37 medical studies)
- Normal minute ventilation: Small and slow breathing at rest is enjoyed by healthy subjects (14 studies)
- Hyperventilation prevalence: Present in over 90% of normal people (24 medical studies)
- HV and hypoxia: How and why deep breathing reduces oxygenation of cells and tissues of all vital organs
- Body-oxygen test (CP test) : How to measure your own breathing and body oxygenation (two in one) using a simple DIY test
- Body oxygen in healthy: Results for the body-oxygen test for healthy people (27 medical studies)
- Body oxygen in sick : Results for the body-oxygen test for sick people (14 medical studies)
- Buteyko Table of Health Zones: Clinical description and ranges for breathing zones: from the critically ill (severely sick) up to super healthy people with maximum possible body oxygenation
- Morning hyperventilation: Why people feel worse and critically ill people are most likely to die during early morning hours

References: pages about CO2 effect:
- Vasodilation: CO2 expands arteries and arterioles facilitating perfusion (or blood supply) to all vital organs
- The Bohr effect: How and why oxygen is released by red blood cells in tissues
- Cell oxygen levels: How alveolar CO2 influences oxygen transport
- Oxygen transport: O2 transport is controlled by vasoconstriction-vasodilation and the Bohr effects, both of which rely on CO2
- Free radical generation: Reactive oxygen species are produced within cells due to anaerobic cell respiration caused by cell hypoxia
- Inflammatory response: Chronic inflammation in fueled by the hypoxia-inducible factor 1, while normal breathing reduces and eliminates inflammation
- Nerve stabilization: People remain calm due to calmative or sedative effects of carbon dioxide in neurons or nerve cells
- Muscle relaxation: Relaxation of muscle cells is normal at high CO2, while hypocapnia causes muscular tension, poor posture and, sometimes, aggression and violence
- Bronchodilation: Dilation of airways (bronchi and bronchioles) is caused by carbon dioxide, and their constriction by hypocapnia (low CO2)
- Blood pH: Regulation of blood pH due to breathing and regulation of other bodily fluids
- CO2: lung damage: Elevated carbon dioxide prevents lung injury and promotes healing of lung tissues
- CO2: Topical carbon dioxide can heal skin and tissues
- Synthesis of glutamine in the brain, CO2 fixation, and other chemical reactions
- Deep breathing myth: Ignorant and naive people promote the idea that deep breathing and breathing more air at rest is beneficial for health
- Breathing control: How is our breathing regulated? Why hypocapnia makes breathing uneven, irregular and erratic.

Or go back to Diseases

If you click the above Facebook like button and "like" this page, I will be nearly "forced" to asnwer your question. You can also tweet this page. Mention this in your comment, and you can ask even more. Thanks.

Disclaimer

Copyright 2013 Artour Rakhimov

Contact details

About Artour Rakhimov (Google profile)