Minute Ventilation in Health and Disease

- Updated on December 9, 2021

Minute Ventilation in Health and Disease 1By Dr. Artour Rakhimov, Alternative Health Educator and Author

What is the norm of breathing? How many liters of air per minute should we breathe while sitting at rest? The physiological norm of minute ventilation can be found in many physiological and medical textbooks. It is about 6 liters per minute (Guyton, 1984; Ganong, 1995). So, let us keep in mind this important number: 6 liters of air per minute. Table 1.1 summarizes information about minute ventilation at rest in different diseased states.

brain-oxygen-chv-hvpt-overbreathing

*One row corresponds to one medical study/publication

Condition Minute

ventilation

N. of

patients

Prevalence of CHV Reference
Normal breathing 6 l/min 0 % Medical textbooks
Heart disease 15 (±4) l/min 22 100% Dimopoulou et al, 2001
Heart disease 16 (±2) l/min 11 100% Johnson et al, 2000
Heart disease 12 (±3) l/min 132 100% Fanfulla et al, 1998
Heart disease 15 (±4) l/min 55 100% Clark et al, 1997
Heart disease 13 (±4) l/min 15 100% Banning et al, 1995
Heart disease 15 (±4) l/min 88 100% Clark et al, 1995
Heart disease 14 (±2) l/min 30 100% Buller et al, 1990
Heart disease 16 (±6) l/min 20 100% Elborn et al, 1990
Pulm hypertension 12 (±2) l/min 11 100% D’Alonzo et al, 1987
Cancer 12 (±2) l/min 40 100% Travers et al, 2008
Diabetes 12-17 l/min 26 100% Bottini et al, 2003
Diabetes 15 (±2) l/min 45 100% Tantucci et al, 2001
Diabetes 12 (±2) l/min 8 100% Mancini et al, 1999
Diabetes 10-20 l/min 28 100% Tantucci et al, 1997
Diabetes 13 (±2) l/min 20 100% Tantucci et al, 1996
Asthma 13 (±2) l/min 16 100% Chalupa et al, 2004
Asthma 15 l/min 8 100% Johnson et al, 1995
Asthma 14 (±6) l/min 39 100% Bowler et al, 1998
Asthma 13 (±4) l/min 17 100% Kassabian et al, 1982
Asthma 12 l/min 101 100% McFadden et al, 1968
COPD 14 (±2) l/min 12 100% Palange et al, 2001
COPD 12 (±2) l/min 10 100% Sinderby et al, 2001
COPD 14 l/min 3 100% Stulbarg et al, 2001
Sleep apnoea 15 (±3) l/min 20 100% Radwan et al, 2001
Liver cirrhosis 11-18 l/min 24 100% Epstein et al, 1998
Hyperthyroidism 15 (±1) l/min 42 100% Kahaly, 1998
Cystic fibrosis* 13 (±2) l/min 10 100% Bell et al, 1996
Cystic fibrosis 11-14 l/min 6 100% Tepper et al, 1983
Epilepsy 13 l/min 12 100% Esquivel et al, 1991
CHV 13 (±2) l/min 134 100% Han et al, 1997
Panic disorder 12 (±5) l/min 12 100% Pain et al, 1991
Bipolar disorder 11 (±2) l/min 16 100% MacKinnon et al, 2007
Dystrophia myotonica 16 (±4) l/min 12 100% Clague et al, 1994

Table 1.1 Minute ventilation of patients with different health problems.

Table 1.1 comments:

  • 1. There are many dozens of other medical investigations into minute ventilation of patients with chronic heart failure, which show similar results to those listed above. (The reason for this is the commonness of this health problem among people and the popularity of the stress-exercise test for heart patients among respiration researchers). Here I have quoted only the results of some typical recent studies.
  • 2. “COPD” means chronic obstructive pulmonary disease.
  • 3. Sometimes, measurement of ventilation produces results, which are smaller than in real conditions. This can happen when the test interferes with the normal breathing pattern, such as when the experiment involves the use of facial masks. Since it is harder to breathe through them, these masks reduce minute ventilation. Breathing through a mouthpiece also leads to breathing less air than in reality. Another effect is connected with bodyweight: people of a lighter weight need less air, as they normally have lower metabolic rates. All these effects should be taken into account when analyzing experimental results. For example, in the quoted study (Bell et al, 1996) patients with cystic fibrosis had minute ventilation of 10.4+-1.4 l/min. Not only were they wearing masks during measurement, but also the average weight of these people was 56.5 kg. Hence, the quoted minute ventilation would probably be equivalent to about 15 l/min for typical adults.
  • 4. Similarly, weight should be taken into account when analyzing the minute ventilation of children. For example, it was reported that 12 children with epilepsy had average minute ventilation of almost 8 l/min (Esquivel et al, 1991). Their average weight was 43 kg, which corresponds to about 12-15 l/min for adults with normal weights, therefore indicating hyperventilation. Numerous other studies also found evidence of hyperventilation in patients with this health condition.

Note, that virtually all tested patients with chronic heart failure over-breathe.

Minute Ventilation in Health and Disease 2

The same was true for these limited studies in relation to diabetes, asthma, and other disorders. However, more experiments are required for these and other health problems in order to be certain about the existing links between breathing and diseases.

It is normal, that such studies can find the prevalence of over-breathing in investigated subjects. A few health conditions where patients breathe less than the norm will be considered below.

Now we can conclude that many sick people breathe too much.

What about breathing rates in modern healthy subjects? This table comprises 14 published medical studies. We see that healthy subjects breathe about 6-7 l/min at rest.

Table. Minute ventilation (or minute breathing rates) at rest in healthy subjects (14 studies)

Condition Minute

ventilation

N. of

subjects

Reference
Normal breathing 6 l/min Medical textbooks
Healthy subjects 7.7 ± 0.3 l/min 19 Douglas et al, 1982
Healthy males 8.4 ± 1.3 l/min 10 Burki, 1984
Healthy males 6.3 l/min 10 Smits et al, 1987
Healthy males 6.1±1.4 l/min 6 Fuller et al, 1987
Healthy subjects 6.1± 0.9 l/min 9 Tanaka et al, 1988
Healthy students 7.0 ± 1.0 l/min 10 Turley et al, 1993
Healthy subjects 6.6 ± 0.6 l/min 10 Bengtsson et al, 1994
Healthy subjects 7.0±1.2 l/min 12 Sherman et al, 1996
Healthy subjects 7.0±1.2 l/min 10 Bell et al, 1996
Healthy subjects 6 ± 1 l/min 7 Parreira et al, 1997
Healthy subjects 7.0 ± 1.1 l/min 14 Mancini et al, 1999
Healthy subjects 6.6 ± 1.1 l/min 40 Pinna et al, 2006
Healthy subjects 6.7 ± 0.5 l/min 17 Pathak et al, 2006
Healthy subjects 6.7 ± 0.3 l/min 14 Gujic et al, 2007

 

We can also consider historical changes in breathing rates for normal subjects.

Table 3. Historical changes in minute ventilation

(or minute breathing rates) at rest for normal subjects

Condition Minute

ventilation

Age N. of

subjects

Reference
Normal breathing 6 l/min 16 Medical textbooks
Normal subjects 4.9 5 Griffith et al, 1929
Normal males 5.3±0.1 27-43 46 Shock et al, 1939
Normal females 4.6±0.1 27-43 40 Shock et al, 1939
Normal subjects 6.9±0.9 100 Matheson et al, 1950
Normal subjects 9.1±4.5 31±7 11 Kassabian et al, 1982
Normal subjects 8.1±2.1 42±14 11 D’Alonzo et al, 1987
Normal subjects 6.3±2.2 12 Pain et al, 1988
Normal males 13±3 40 (av.) 12 Clague et al, 1994
Normal subjects 9.2±2.5 34±7 13 Radwan et al, 1995
Normal subjects 15±4 28-34 12 Dahan et al, 1995
Normal subjects 12±4 55±10 43 Clark et al, 1995
Normal subjects 12±2 41±2 10 Tantucci et al, 1996
Normal subjects* 11±3 53±11 24 Clark et al, 1997
Normal subjects 8.1±0.4 34±2 63 Meessen et al. 1997
Normal females 9.9 20-28 23 Han et al, 1997
Normal males 15 20-28 47 Han et al, 1997
Normal females 10 29-60 42 Han et al, 1997
Normal males 11 29-62 42 Han et al, 1997
Normal subjects 13±3 36±6 10 Tantucci et al, 1997
Normal subjects 12±1 65±2 10 Epstein et al, 1996
Normal subjects 12±1 12-69 20 Bowler et al, 1998
Normal subjects 10±6 39±4 20 DeLorey et al, 1999
Normal seniors 12±4 70±3 14 DeLorey et al, 1999
Normal elderly* 14±3 88±2 11 DeLorey et al, 1999
Normal subjects 17±1 41±2 15 Tantucci et al, 2001
Normal subjects 10±0.5 10 Bell et al, 2005
Normal subjects 8.5±1.2 30±8 69 Narkiewicz, 2006
Normal females 10±0.4 11 Ahuja et al, 2007
Normal subjects 12±2 62±2 20 Travers et al, 2008

Extract from Dr. Artour Rakhimov's Amazon book "Normal Breathing: The Key to Vital Health", also available in PDF.