Hypercapnia (Hypercarbia): Causes and Treatment

Definition of hypercapnia

Hypercapnia (or hypercarbia) is generally defined as an abnormally high level of carbon dioxide (e.g., more than 45 mm Hg) in the arterial blood. Hypercarbia is a medical term that was more common many decades ago, but it is still popular in some areas of the world and among some medical professionals. We are going to use both terms ("hypercapnia" and "hypercarbia") interchangeably.

The word "hypercapnia" is currently most commonly used in emergency medicine and critical care. However, hypercarbia can be caused by different factors and conditions. Generally, there are 5 different “worlds” or situations, with different meaning of hypercarbia. They are all described below.

Content of this web page:
1. Hypercarbia in emergency medicine and critical care
2. Hypercapnia related to manipulation of artificial ventilation due to beneficial CO2 effects (e.g., permissive hypercapnia)
3. Hypercapnia during treatment with carbogen and physiological tests
4. Hypercarbia due to chronic diseases
5. Hypercapnia during breathing exercises
6. Treatment of hypercapnia

1. Causes of hypercarbia related to emergency medicine and critical care

Woman - Sleep Apnea, Hypercapnia: breathing with CPAP Severe hypercapnia can be a very serious concern for respiratory specialists, emergency and critical care workers. It can be divided into chronic and acute.

Chronic hypercarbia can often accompany various respiratory conditions that compromise gas exchange in the lungs leading to inability of CO2 to diffuse from the venous blood in the alveoli and/or inability of the airways to provide normal ventilation of all alveoli. Common causes of hypercapnia include:
- respiratory diseases (e.g., asthma, bronchitis, emphysema, chronic lung disease - COPD)
- infectious diseases (bacterial pneumonia, bronchopneumonia, SARS or severe acute respiratory syndrome, botulism and pulmonary tuberculosis pulmonary),
- inflammatory disorders (pulmonary sarcoidosis)
- cystic fibrosis (mucoviscidosis)
- neoplastic disorders (metastatic lung disease)
- pulmonary edema
- poisoning non-bacterial agents (asbestosis, berylliosis, coal workers lung or anthracosis, silicosis, and silicotuberculosis)
- metabolic disorders (obesity)
- sleep apnea syndrome
- primary hypoventilation
- Pickwick's syndrome.

Acute hypercapnia causes include
- status epilepticus
- congestive heart failure
- respiratory failure or pulmonary insufficiency
- asphyxia or suffocation
- respiratory dead space excess
- breathing pure oxygen
- ventilator malfunction
- presence of foreign bodies in airways
- respiratory arrest
- coma
- overdose of medical drugs or respiratory suppressants (e.g., sedative drugs, salicylate intoxication/overdose, curare, morphine and other opiates).

In this setting hypercarbia is a life-threatening condition that requires professional medical attention.

2. Hypercapnia caused by manipulation of artificial ventilation due to beneficial CO2 effects (e.g., permissive hypercapnia)

The fathers of respiratory physiology and authors of the first medical textbooks on respiration definitely had a more objective view on the properties of CO2 (Haldane & Priestley, 1935; Henderson 1940). Later, the dangerous and unwise practice of indiscriminate use of pure (100%) oxygen became a norm in emergency care. However, since the 1990’s many medical respiratory professionals regained sanity. As a result, hundreds of clinical studies have been published in relation to permissive hypercapnia. (The term “permissive hypercapnia” defines a ventilatory strategy used for acute respiratory failure in which the lungs are ventilated with a low inspiratory volume and pressure.) Permissive hypercarbia is currently used for:
- preterm infants (Miller & Carlo, 2007)
- neonates (Toms & Ambalavanan, 2004; Varughese et al, 2002)
- pediatric acute lung injury (Rotta & Steinhorn, 2006)
- prevention of lung injuries (Lafgey et al, 2004)
- ARDS or acute respiratory distress syndrome (Lewandowski, 1996; Hickling & Joyce, 1995) and some other situations.

3. Hypercapnia during treatment with carbogen and physiological tests

Carbon dioxide model The terms “hypercapnia” and “hypercapnic” are also used in situations when CO2 gas is added to inspired air for treatment or testing various physiological effects. Gas mixtures (with 1%, 2%, 2.5%, or 5% CO2 and various O2 contents ranging from 20% to maximum) are used for testing patients with asthma, panic attacks, and treatment of cancer patients with carbogen mixtures for better oxygenation of tumors (carbogen gas, by definition, has only CO2 and O2). Note that during these studies the subjects usually do not have elevated CO2 level in the arterial blood. In fact, many of them have less than 40 mm Hg which is the normal arterial CO2 value. Thus, many researchers apply the term “hypercarbia” to a relative increase in arterial blood CO2 due to breathing an air with higher CO2 content. (Furthermore, such CO2-rich air may trigger panic attacks and some subjects may even lower their already low arterial blood CO2 values.)

4. Hypercarbia due to chronic diseases

Which health problems are routinely characterized by too high arterial CO2 levels? This generally relates to severe forms of asthma, cystic fibrosis, COPD (emphysema and bronchitis included) and some other conditions with reduced ventilation-perfusion ratio and hypoxemia (reduced oxygenation of the arterial blood). What is the mechanism or pathophysiology of these changes? Consider medical studies related to breathing rates in people with these conditions.

Minute ventilation rates (chronic diseases)

Condition	Minute ventilation	Number of people	All references or click below for abstracts
Normal breathing	6 l/min	-	Medical textbooks
Healthy Subjects	6-7 l/min	>400	Results of 14 studies
COPD	14 (±2) l/min	12	Palange et al, 2001
COPD	12 (±2) l/min	10	Sinderby et al, 2001
COPD	14 l/min	3	Stulbarg et al, 2001
Asthma	13 (±2) l/min	16	Chalupa et al, 2004
Asthma	15 l/min	8	Johnson et al, 1995
Asthma	14 (±6) l/min	39	Bowler et al, 1998
Asthma	13 (±4) l/min	17	Kassabian et al, 1982
Asthma	12 l/min	101	McFadden & Lyons, 1968
Cystic fibrosis	15 L/min	15	Fauroux et al, 2006
Cystic fibrosis	10 L/min	11	Browning et al, 1990
Cystic fibrosis*	10 L/min	10	Ward et al, 1999
CF and diabetes*	10 L/min	7	Ward et al, 1999
Cystic fibrosis	16 L/min	7	Dodd et al, 2006
Cystic fibrosis	18 L/min	9	McKone et al, 2005
Cystic fibrosis*	13 (±2) l/min	10	Bell et al, 1996
Cystic fibrosis	11-14 l/min	6	Tepper et al, 1983

Patients and MDs We see elevated minute ventilation (up to about 2-2.5 times more than the norm). This leads to low alveolar carbon dioxide levels. CO2 is a potent dilator of airways (bronchodilator) and is crucial for repair of alveoli (see references for hypocapnic lung injury effects below). As a result, overbreathing, is the main factor that destroy lung tissue in these groups of patients and worsen oxygen delivery to body cells.

There are additional effects of hyperventilation that cause: cell hypoxia, the suppressed immune system (hence, frequent respiratory infections), reduced efficiency of ion pumps in mucosal layers due to tissue hypoxia causing more viscous mucus (with devastating health effects in cystic fibrosis), overcooling and drying of airways, irritation of cough receptors located in the larynx and many other negative effects.

5. Hypercapnia during breathing exercises

Group of people practicing breathwork Numerous breathing exercises and techniques naturally cause increased CO2. Thus, hypercapnia is a normal outcome of Pranayama, Buteyko reduced breathing exercise (the main breathing exercise in the Buteyko breathing technique), Frolov breathing device therapy and application of many other breathing devices due to increased respiratory dead volume (Karbonic, Cosmic Breath, and many others).

Furthermore, clinical experience of Russian doctors suggests that people in super health with diaphragmatic breathing and only 3-8 breaths/minute for their automatic respiratory frequency at rest and about 2-4 L/min for minute ventilation have abnormally high arterial CO2 (e.g., more than 45 mm Hg), as it is clear from the Buteyko Table of Health Zones. Yoga masters also have very slow and light breathing at rest. For Dr. Buteyko quotes about yoga secret of super health, which is based on hypercapnia, visit Yoga Breathing web page.

6. Treatment of hypercapnia or hypercarbia

Treatment of hypercapnia generally relates to chronic conditions, such as severe asthma, chronic bronchitis, emphysema, and other disorders. For all these conditions, hypercapnia is accompanied by abnormally low oxygen saturation (hypoxemia) due to hyperventilation (see the Table above). The detailed information about treatment of hypercarbia can be found on the page Treatment of Hyperventilation that provides also treatment for hypoxemia.

References: CO2 Effects Web Pages
Vasodilation: CO2 expands arteries and arterioles facilitating perfusion (or blood supply) to all vital organs
The Bohr effect How and why oxygen is released by red blood cells in tissues
Cell Oxygen Levels and oxygen transport are controlled by alveolar CO2 and breathing
Oxygen Transport depends on breathing and these two effects (Vasoconstriction-Vasodilation and the Bohr effect) are parts of two diagrams that summarize influences of hypocapnia (low CO2 content in the blood and cells) on circulation and O2 delivery
Free Radical Generation takes place due to anaerobic cell respiration caused by cell hypoxia. Hence, antioxidant defenses of the human body are also regulated by CO2 and breathing
Inflammatory Response is controlled by breathing since hypoxia leads to or intensifies chronic inflammation through over-expression of the hypoxia-inducible factor 1, while normal breathing reduces these processes
Nerve stabilization takes place due to calmative or sedative effects of carbon dioxide in neurons or nerve cells
Muscle relaxation or relaxation of muscle cells is normal at high CO2, while hypocapnia causes muscular tension, poor posture and, sometimes, aggression and violence
Brochodilation - dilation of airways (bronchi and bronchioles) by carbon dioxide, and their constriction due to hypocapnia
CO2: Best Natural Cough Suppressant and "home remedy" since it calms urge-to-cough nerve receptors located in the tracheobronchial tree and larynx
Blood pH regulation and regulation of other bodily fluids
CO2: Lung Damage Healer: Elevated carbon dioxide prevents injury and promotes healing of lung tissues
CO2: Skin and Tissue Healer
Synthesis of Glutamine in the Brain, CO2 fixation, and other chemical reactions
CO2 myth "CO2 is a toxic waste gas" myth
Breathing control How is our breathing regulated? Why hypocapnia makes breathing uneven and erratic?

References

- Haldane JS and Priestley JG, Respiration, 2nd Edition, Oxford University Press, 1935.
- Hasselbalch: Bioch. Zeitsch., 1912, xlvi (46), 416.
- Henderson Y, Professor, MD, PhD, Carbon Dioxide, from the: Cyclopedia of Medicine, 1940.
- Hickling KG, Joyce C. Permissive hypercapnia in ARDS and its effect on tissue oxygenation. Acta Anaesthesiol Scand Suppl. 1995; 107: 201-8.
- Laffey JG, O'Croinin D, McLoughlin P, Kavanagh BP. Permissive hypercapnia--role in protective lung ventilatory strategies. Intensive Care Med. 2004 Mar; 30(3): 347-56.
- Lewandowski K. Permissive hypercapnia in ARDS: just do it? Intensive Care Med. 1996 Mar;22(3):179-81.
- Miller JD, Carlo WA. Safety and effectiveness of permissive hypercapnia in the preterm infant. Curr Opin Pediatr. 2007 Apr; 19(2): 142-4.
- Rotta AT, Steinhorn DM. Is permissive hypercapnia a beneficial strategy for pediatric acute lung injury? Respir Care Clin N Am. 2006 Sep; 12(3): 371-87.
-Toms R, Ambalavanan N. Permissive hypercapnia during mechanical ventilation of neonates. Indian Pediatr. 2004 Aug; 41(8): 775-8.
- Varughese M, Patole S, Shama A, Whitehall J. Permissive hypercapnia in neonates: the case of the good, the bad, and the ugly. Pediatr Pulmonol. 2002 Jan; 33(1): 56-64.
- Woodgate PG, Davies MW. Permissive hypercapnia for the prevention of morbidity and mortality in mechanically ventilated newborn infants. Cochrane Database Syst Rev. 2001;(2):CD002061.

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