Genetic Diseases Appear Due to Low Body Oxygen
Based on hundreds of medical research studies quoted on this website, we can make the following conclusions related to cell oxygenation and its leading role in understanding human genetics and development of numerous genetic disorders and diseases:
1. Virtually all multifactorial and many Mendelian and common genetic disorders are based on cellular hypoxia (low oxygenation of tissues).
2. Heart disease, diabetes, cancer, asthma, COPD, cystic fibrosis, and many other diseases exist only in conditions of abnormal breathing (see Chronic Hyperventilation Syndrome - over 40 medical research studies with 100% prevalence of chronic hyperventilation).
3. Chronic overbreathing or breathing more air than the medical norm cannot increase hemoglobin oxygenation (which is about 98% during minuscule normal breathing), but only leads to CO2 losses.
5. People, who have normal breathing parameters or breathe even less (and slower) than the medical norm, do not develop chronic diseases or multifactorial and many common and Mendelian disorders. These people do not suffer from symptoms (when genes are "expressed"), in spite of their hereditary predisposition or presence of "bad genes".
Hence, respiratory parameters and cell oxygenation, usually in dose dependent manner, control expression of symptoms of multifactorial genetic disorders. This relationship is reflected in the Buteyko Table of Health Zones, which suggests 12 different health zones depending on personal breathing parameters.
Lifestyle and environmental factors, including exercise and diet, do influence dynamics of these genetic disorders through their effects on respiratory parameters and oxygenation of people. (For example, overeating and stress makes breathing deeper and faster, while relaxation and physical exercise, when correctly done, slow down our breathing at rest, due to adaptation to higher CO2, later.)
Note that chromosomal genetic disorders or chromosomes diseases (e.g., Down syndrome or trisomy) have no relation to cell respiration and breathing process. However, if carriers of these chromosomal genetic disorders have abnormal breathing parameters and reduced body oxygenation, they will develop their multifactorial genetic disorders or "diseases of civilization" depending on the degree of their hyperventilation.
Single-gene genetic diseases (also called Mendelian or monogenic disorders) and mitochondrial conditions, since they are based on cell hypoxia, are also expressed only in conditions of chronic hyperventilation. This relates to, for example, cystic fibrosis and many other diseases.
* Illustrations by Victor Lunn-Rockliffe
Reference pages: Breathing norms and the DIY body oxygen test:
- Breathing norms: Parameters, graph, and description of the normal breathing pattern
- Body-oxygen test (CP test) : How to measure your own breathing and body oxygenation (two in one) using a simple DIY test
References: pages about CO2 effect:
- Vasodilation: CO2 expands arteries and arterioles facilitating perfusion (or blood supply) to all vital organs
- The Bohr effect: How and why oxygen is released by red blood cells in body tissues
- Nerve stabilization: Carbon dioxide has powerful calmative and sedative effects on brain neurons and nerve cells
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