Human genetics and diseases
This webpage is devoted to scientific analysis and understanding of the role of human genetics in development of multifactorial genetic disorders, including heart disease, cancer, hypertension, Alzheimer’s disease, arthritis, diabetes, asthma, and obesity. What is the role of human genetics (heredity or genes) in the development of these chronic diseases? Why do some people develop chronic genetic disorders or diseases, while others, with the same inheritance or genes not? What is the exact mechanism of progression and clinical remission of chronic diseases with multifactorial inheritance ? How can lifestyle factors influence development of these disorders (e.g., effects of exercise and diet on heart disease)?
Based on hundreds of medical research studies quoted on this website, we can make the following conclusions related to cell oxygenation and its leading role in understanding human genetics and diseases:
1. Virtually all multifactorial genetic disorders are based on cellular hypoxia (low oxygenation of tissues).
2. Heart disease, diabetes, cancer, asthma, COPD and many other diseases exist only in conditions of abnormal breathing (see this Table for breathing rates in the sick - over 30 medical research studies - with 100% prevalence of chronic hyperventilation).
3. Respiratory abnormalities (mainly respiratory alkalosis) are the leading causes of mortality in the severely sick and terminally ill patients due to their very heavy and deep breathing during last days/weeks of life.
4. Chronic overbreathing or breathing more air than the medical norm cannot increase haemoglobin oxygenation (which is about 98% during minuscule normal breathing), but only leads to CO2 losses.
5. Arterial hypocapnia (CO2 deficiency) leads to chest breathing, hypocapnic vasoconstriction and suppressed Bohr effect. All these processes reduce oxygen delivery to vital organs.
6. People, who have normal breathing parameters or breathe even less (and slower) than the medical norm, do not develop chronic diseases and do not suffer from symptoms (when genes are "expressed"), in spite of their hereditary predisposition or presence of "bad genes".
Hence, respiratory parameters and cell oxygenation, in dose dependent manner, control expression of symptoms of multifactorial genetic disorders. This relationship is reflected in the Buteyko Table of Health Zones, which suggests 12 different health zones depending on personal breathing parameters.
All lifestyle and environmental factors, including exercise and diet, do influence dynamics of these genetic diseases through their effects on respiratory parameters and oxygenation of people. (For example, overeating and stress makes breathing deeper and faster, while relaxation and physical exercise, when correctly done, slow down our breathing at rest, due to adaptation to higher CO2, later.)
Note that chromosomal genetic disorders or chromosomes diseases (e.g., Down syndrome or trisomy) have no relation to cell respiration and breathing process. However, if carriers of these chromosomal genetic disorders have abnormal breathing parameters and reduced body oxygenation, they will develop their multifactorial genetic disorders or "diseases of civilization" depending on the degree of their hyperventilation.
Single-gene genetic diseases (also called Mendelian or monogenic disorders) and mitochondrial conditions, since they are based on cell hypoxia, are also expressed only in conditions of chronic hyperventilation. This relates to, for example, cystic fibrosis and many other diseases.
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Related webpage: When patients are asked to deliberately hyperventilate, they experience those health problems which are ... in their genes! This test is used by MDs worldwide for many decades. Medical research studies and trials found that hyperventilation provocation test is a highly specific test for coronary artery spasms (angina pain due to heart disease), asthma, panic attacks, epilepsy, ... |
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