Genetics, Common Genetic Disorders, Chronic Diseases and Body Oxygen

Video: Genetics: How Bad Genes Cause Poor Health, Diseases, and Low Body O2. For many chronic genetic diseases, we can easily prove that deep and fast breathing immediately produces or triggers their main symptoms, such as angina spasms (heart attacks), seizures, acute asthma or asthma attacks, panic and many others. It is called the hyperventilation provocation test. Many sick people experience those problems that are in their genes. This test has been used by MDs worldwide for many decades. Medical research studies and trials found that this test is a highly specific test for coronary artery spasms, asthma, panic attacks, epilepsy seizures, ... More about hyperventilation provocation test.

Common genetic disorders triggered by overbreathing Based on hundreds of medical research studies quoted on this website, we can make the following conclusions related to cell oxygenation and its leading role in understanding human genetics and development of numerous genetic disorders and diseases:

1. Virtually all multifactorial and many Mendelian and common genetic disorders are based on cellular hypoxia (low oxygenation of tissues).

2. Heart disease, diabetes, cancer, asthma, COPD, cystic fibrosis, and many other diseases exist only in conditions of abnormal breathing (see Chronic Hyperventilation Syndrome - over 40 medical research studies with 100% prevalence of chronic hyperventilation).

3. Chronic overbreathing or breathing more air than the medical norm cannot increase hemoglobin oxygenation (which is about 98% during minuscule normal breathing), but only leads to CO2 losses.

People with mouth breathing 4. Arterial hypocapnia (CO2 deficiency) leads to chest breathing, hypocapnic vasoconstriction and suppressed Bohr effect. These processes reduce oxygen delivery to all vital organs.

5. People, who have normal breathing parameters or breathe even less (and slower) than the medical norm, do not develop chronic diseases or multifactorial and many common and Mendelian disorders. These people do not suffer from symptoms (when genes are "expressed"), in spite of their hereditary predisposition or presence of "bad genes".

Hence, respiratory parameters and cell oxygenation, usually in dose dependent manner, control expression of symptoms of multifactorial genetic disorders. This relationship is reflected in the Buteyko Table of Health Zones, which suggests 12 different health zones depending on personal breathing parameters.

Medical doctors smiling Lifestyle and environmental factors, including exercise and diet, do influence dynamics of these genetic disorders through their effects on respiratory parameters and oxygenation of people. (For example, overeating and stress makes breathing deeper and faster, while relaxation and physical exercise, when correctly done, slow down our breathing at rest, due to adaptation to higher CO2, later.)

Note that chromosomal genetic disorders or chromosomes diseases (e.g., Down syndrome or trisomy) have no relation to cell respiration and breathing process. However, if carriers of these chromosomal genetic disorders have abnormal breathing parameters and reduced body oxygenation, they will develop their multifactorial genetic disorders or "diseases of civilization" depending on the degree of their hyperventilation.

Single-gene genetic diseases (also called Mendelian or monogenic disorders) and mitochondrial conditions, since they are based on cell hypoxia, are also expressed only in conditions of chronic hyperventilation. This relates to, for example, cystic fibrosis and many other diseases.

* Illustrations by Victor Lunn-Rockliffe

Reference Web Pages: Breathing norms, Medical Graphs and Tables about Breathing Rates (Minute Ventilation) and Body Oxygen in Healthy, Normal and Sick People
Breathing norms Parameters, graph, and description of the normal breathing pattern
6 breathing myths 6 myths about breathing and body oxygenation (prevalence: over 90%)
Hyperventilation Definitions of hyperventilation: their advantages and weak points
Hyperventilation Syndrome in the Sick. Table 1. Western scientific evidence about prevalence of CHV (chronic hyperventilation) in patients with various chronic conditions (34 medical studies)
Normal Minute Ventilation in Healthy Subjects: Easy and Light Breathing (14 Studies)
Hyperventilation Prevalence Present in Over 90% of Normal People (24 medical publications)
HV and hypoxia How and why deep breathing reduces oxygenation of cells and tissues of all vital organs
Body oxygen test How to measure your own breathing and body oxygenation (a simple DIY test)
Body oxygen in healthy Table 4. CP (body oxygen level) in healthy people (27 medical studies)
Body oxygen in sick Table 5. CP (body oxygen level) in sick people (14 medical studies)
Buteyko Table of Health Zones with clinical description of most common zones
Morning HV Morning hyperventilation effect or how and why critically ill people are most likely to die during early morning hours

References: CO2 Effects Web Pages
Vasodilation: CO2 expands arteries and arterioles facilitating perfusion (or blood supply) to all vital organs
The Bohr effect How and why oxygen is released by red blood cells in tissues
Cell Oxygen Levels and oxygen transport are controlled by alveolar CO2 and breathing
Oxygen Transport depends on breathing and these two effects (Vasoconstriction-Vasodilation and the Bohr effect) are parts of two diagrams that summarize influences of hypocapnia (low CO2 content in the blood and cells) on circulation and O2 delivery
Free Radical Generation takes place due to anaerobic cell respiration caused by cell hypoxia. Hence, antioxidant defenses of the human body are also regulated by CO2 and breathing
Inflammatory Response is controlled by breathing since hypoxia leads to or intensifies chronic inflammation through over-expression of the hypoxia-inducible factor 1, while normal breathing reduces these processes
Nerve stabilization takes place due to calmative or sedative effects of carbon dioxide in neurons or nerve cells
Muscle relaxation or relaxation of muscle cells is normal at high CO2, while hypocapnia causes muscular tension, poor posture and, sometimes, aggression and violence
Brochodilation - dilation of airways (bronchi and bronchioles) by carbon dioxide, and their constriction due to hypocapnia
CO2: Best Natural Cough Suppressant and "home remedy" since it calms urge-to-cough nerve receptors located in the tracheobronchial tree and larynx
Blood pH regulation and regulation of other bodily fluids
CO2: Lung Damage Healer: Elevated carbon dioxide prevents injury and promotes healing of lung tissues
CO2: Skin and Tissue Healer
Synthesis of Glutamine in the Brain, CO2 fixation, and other chemical reactions
CO2 myth "CO2 is a toxic waste gas" myth
Breathing control How is our breathing regulated? Why hypocapnia makes breathing uneven and erratic?

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