Genetic Diseases Appear Due to Low Body Oxygen
Video: Genetics, Diseases, and Low Body O2. For many chronic genetic diseases, we can easily prove that deep and fast breathing immediately produces or triggers their main symptoms, such as angina spasms (heart attacks), seizures, asthma attacks, panic and many others. It is called the hyperventilation provocation test. Many sick people experience those problems that are in their genes. Here is more about hyperventilation provocation test.
Based on hundreds of medical research studies quoted on this website, we can make the following conclusions related to cell oxygenation and its leading role in understanding human genetics and development of numerous genetic disorders and diseases:
1. Virtually all multifactorial and many Mendelian and common genetic disorders are based on cellular hypoxia (low oxygenation of tissues).
2. Heart disease, diabetes, cancer, asthma, COPD, cystic fibrosis, and many other diseases exist only in conditions of abnormal breathing (see Chronic Hyperventilation Syndrome - over 40 medical research studies with 100% prevalence of chronic hyperventilation).
3. Chronic overbreathing or breathing more air than the medical norm cannot increase hemoglobin oxygenation (which is about 98% during minuscule normal breathing), but only leads to CO2 losses.
5. People, who have normal breathing parameters or breathe even less (and slower) than the medical norm, do not develop chronic diseases or multifactorial and many common and Mendelian disorders. These people do not suffer from symptoms (when genes are "expressed"), in spite of their hereditary predisposition or presence of "bad genes".
Hence, respiratory parameters and cell oxygenation, usually in dose dependent manner, control expression of symptoms of multifactorial genetic disorders. This relationship is reflected in the Buteyko Table of Health Zones, which suggests 12 different health zones depending on personal breathing parameters.
Lifestyle and environmental factors, including exercise and diet, do influence dynamics of these genetic disorders through their effects on respiratory parameters and oxygenation of people. (For example, overeating and stress makes breathing deeper and faster, while relaxation and physical exercise, when correctly done, slow down our breathing at rest, due to adaptation to higher CO2, later.)
Note that chromosomal genetic disorders or chromosomes diseases (e.g., Down syndrome or trisomy) have no relation to cell respiration and breathing process. However, if carriers of these chromosomal genetic disorders have abnormal breathing parameters and reduced body oxygenation, they will develop their multifactorial genetic disorders or "diseases of civilization" depending on the degree of their hyperventilation.
Single-gene genetic diseases (also called Mendelian or monogenic disorders) and mitochondrial conditions, since they are based on cell hypoxia, are also expressed only in conditions of chronic hyperventilation. This relates to, for example, cystic fibrosis and many other diseases.
* Illustrations by Victor Lunn-Rockliffe
Reference pages: Breathing norms and medical facts:
- Breathing norms: Parameters, graph, and description of the normal breathing pattern
- 6 breathing myths: Myths and superstitions about breathing and body oxygenation (prevalence: over 90%)
- Hyperventilation: Definitions of hyperventilation: their advantages and weak points
- Hyperventilation syndrome: Western scientific evidence about prevalence of chronic hyperventilation in patients with chronic conditions (37 medical studies)
- Normal minute ventilation: Small and slow breathing at rest is enjoyed by healthy subjects (14 studies)
- Hyperventilation prevalence: Present in over 90% of normal people (24 medical studies)
- HV and hypoxia: How and why deep breathing reduces oxygenation of cells and tissues of all vital organs
- Body-oxygen test (CP test) : How to measure your own breathing and body oxygenation (two in one) using a simple DIY test
- Body oxygen in healthy: Results for the body-oxygen test for healthy people (27 medical studies)
- Body oxygen in sick : Results for the body-oxygen test for sick people (14 medical studies)
- Buteyko Table of Health Zones: Clinical description and ranges for breathing zones: from the critically ill (severely sick) up to super healthy people with maximum possible body oxygenation
- Morning hyperventilation: Why people feel worse and critically ill people are most likely to die during early morning hours
References: pages about CO2 effect:
- Vasodilation: CO2 expands arteries and arterioles facilitating perfusion (or blood supply) to all vital organs
- The Bohr effect: How and why oxygen is released by red blood cells in tissues
- Cell oxygen levels: How alveolar CO2 influences oxygen transport
- Oxygen transport: O2 transport is controlled by vasoconstriction-vasodilation and the Bohr effects, both of which rely on CO2
- Free radical generation: Reactive oxygen species are produced within cells due to anaerobic cell respiration caused by cell hypoxia
- Inflammatory response: Chronic inflammation in fueled by the hypoxia-inducible factor 1, while normal breathing reduces and eliminates inflammation
- Nerve stabilization: People remain calm due to calmative or sedative effects of carbon dioxide in neurons or nerve cells
- Muscle relaxation: Relaxation of muscle cells is normal at high CO2, while hypocapnia causes muscular tension, poor posture and, sometimes, aggression and violence
- Bronchodilation: Dilation of airways (bronchi and bronchioles) is caused by carbon dioxide, and their constriction by hypocapnia (low CO2)
- Blood pH: Regulation of blood pH due to breathing and regulation of other bodily fluids
- CO2: lung damage: Elevated carbon dioxide prevents lung injury and promotes healing of lung tissues
- CO2: Topical carbon dioxide can heal skin and tissues
- Synthesis of glutamine in the brain, CO2 fixation, and other chemical reactions
- Deep breathing myth: Ignorant and naive people promote the idea that deep breathing and breathing more air at rest is beneficial for health
- Breathing control: How is our breathing regulated? Why hypocapnia makes breathing uneven, irregular and erratic.
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