Cystic Fibrosis Life Expectancy Depends on Body-O2 Levels
fibrosis life expectancy correlates with O2 content in body cells. Recent medical studies
(see links below) discovered that abnormalities related to cystic fibrosis transmembrane
conductance regulator (CFTR) mutation gene are triggered by tissue hypoxia
(low O2 level in body cells). The main CFTR-related abnormality in CF is
ineffective work of ionic pumps and reduced transfer of ions across mucosal
surfaces. However, even in healthy people, this effect is controlled by O2
levels in cells.
Soviet Buteyko breathing doctors started to treat people with CF in the
1970's, and many of their patients are still alive (as of 2012). In
fact, Soviet and Russian MDs claim that as soon as people with CF have over 40 s for the body-oxygen test, they can expect at least normal life
expectancy (as ordinary people). How and why?
Medical studies that measured
respiratory parameters found that 100% of CF patients suffer from
chronic hyperventilation (breathing much more than the medical norm, or up to
leads to alveolar hypocapnia (low CO2 levels in the lungs) which destroys the
tissue of the
lungs (see Cystic fibrosis in lungs).
Minute ventilation in CF patients in these medical studies ranged from 10
to 18 Liters per minute at rest (adjusted to 70-kg normal weight), while the
medical norm is only 6 L/min.
Decades of medical research have conclusively shown that chronic
hyperventilation has numerous adverse effects on all systems and organs of the
human body, including destruction of lung tissue, more severe problems with
digestion and blood glucose control and many others. For an overview of CF, click here.
A large group of Russian MDs have developed and applied a breathing therapy
(the Buteyko breathing technique) for CF and revealed the following
relationships between respiratory parameters and life expectancy or prognosis in
parameters and cystic fibrosis life expectancy
||Body O2 range
||Stages of the disease
|Symptoms and prognosis
|> 30 breaths/min
||Quickly developing and severe problems with lungs (possible
cor pulmonale), chronic indigestion, etc.
||Clinical stage (hospitalization or
palliative care is required)
|Less than 1-2 years
||Worsened health state with progressive respiratory deterioration: bronchitis
and bronchiolitis transform into bronchiectasis; possible
complications include hemoptysis and pneumothorax.
||Moderate individual symptoms
||Up to 30-40 years
||A typical patient with classical symptoms of mild cystic fibrosis
including chronic infections, poor exercise tolerance, inflammation, GI symptoms, ...
||Initial stage of the disease
||Up to 40-60 years
||Mild GI symptoms; slight deterioration in lung function tests
|< 12 breaths/min
||over 40 s 24/7
||No symptoms, normal life expectancy
These Buteyko doctors found that damage to lungs, sinuses, pancreas, liver, intestines, and sex organs in
cystic fibrosis is proportional to the degree of respiratory
abnormalities, while a complete clinical remission in patients with cystic
fibrosis takes place in cases of breathing normalization. Patients
with cystic fibrosis have an excellent prognosis and normal life expectancy
if they can normalize their breathing pattern. At the same time, low body O2 is
one of the central factors of reduced
cystic fibrosis life expectancy.
It should be kept in mind that cystic fibrosis affects the lungs and
alveoli so that the development of this medical condition leads to
increased ventilation-perfusion mismatch and problems with effective
gas exchange. Another practical aspect related to cystic fibrosis is
that for the overwhelming majority of CF patients, the lowest body
oxygenation and heaviest breathing (or worst respiratory parameters)
take place during early morning hours (or the last portion of the night
sleep) due to the Sleep Heavy Breathing Effect. Obviously, the morning
CP (body-oxygen test) is the main parameter that influences prognosis,
stages, cystic fibrosis life expectancy and quality of life in CF
References: Oxygen and cystic fibrosis.
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