Cystic Fibrosis Life Expectancy Depends on Body-O2 Levels
Cystic fibrosis life expectancy correlates with O2 content in body cells. Recent medical studies (see links below) discovered that abnormalities related to cystic fibrosis transmembrane conductance regulator (CFTR) mutation gene are triggered by tissue hypoxia (low O2 level in body cells). The main CFTR-related abnormality in CF is ineffective work of ionic pumps and reduced transfer of ions across mucosal surfaces. However, even in healthy people, this effect is controlled by O2 levels in cells.
Over 170 Soviet Buteyko breathing doctors started to treat people with CF in the 1970's, and many of their patients are still alive (as of 2012). In fact, Soviet and Russian MDs claim that as soon as people with CF have over 40 s for the body-oxygen test, they can expect at least normal life expectancy (as ordinary people). How and why?
Medical studies that measured respiratory parameters found that 100% of CF patients suffer from chronic hyperventilation (breathing much more than the medical norm, or up to 160-300%). Overbreathing leads to alveolar hypocapnia (low CO2 levels in the lungs) which destroys the tissue of the lungs (see Cystic fibrosis in lungs). Minute ventilation in CF patients in these medical studies ranged from 10 to 18 Liters per minute at rest (adjusted to 70-kg normal weight), while the medical norm is only 6 L/min.
Minute ventilation in cystic fibrosis patients at rest
|Normal breathing||6 L/min||-||Medical textbooks|
|Healthy subjects||6-7 L/min||>400||Results of 14 studies|
|Cystic fibrosis||15 L/min||15||Fauroux et al, 2006|
|Cystic fibrosis*||13 (±2) L/min||10||Bell et al, 1996|
|Cystic fibrosis||10 L/min||11||Browning et al, 1990|
|Cystic fibrosis||11-14 L/min||6||Tepper et al, 1983|
|Cystic fibrosis*||10 L/min||10||Ward et al, 1999|
|CF and diabetes*||10 L/min||7||Ward et al, 1999|
|Cystic fibrosis||16 L/min||7||Dodd et al, 2006|
|Cystic fibrosis||18 L/min||9||McKone et al, 2005|
Click here for all Cystic Fibrosis References
Decades of medical research have conclusively shown that chronic hyperventilation has numerous adverse effects on all systems and organs of the human body, including destruction of lung tissue, more severe problems with digestion and blood glucose control and many others. For an overview of CF, click here.
A large group of Russian MDs have developed and applied a breathing therapy (the Buteyko breathing technique) for CF and revealed the following relationships between respiratory parameters and life expectancy or prognosis in CF patients:
Respiratory parameters and cystic fibrosis life expectancy
|Respiratory frequency||Alveolar CO2||Body O2 range||Stages of the disease||Expected life
|Symptoms and prognosis|
|> 30 breaths/min||<3.5%||1-5 seconds||End-stage disease||Some months||Quickly developing and severe problems with lungs (possible cor pulmonale), chronic indigestion, etc.|
|26-30 breaths/min||3.5-4.0%||6-10 s||Clinical stage (hospitalization or
palliative care is required)
|Less than 1-2 years||Worsened health state with progressive respiratory deterioration: bronchitis and bronchiolitis transform into bronchiectasis; possible complications include hemoptysis and pneumothorax.|
|20-26 breaths/min||4.0-4.5%||11-20 s||Moderate individual symptoms||Up to 30-40 years||A typical patient with classical symptoms of mild cystic fibrosis including chronic infections, poor exercise tolerance, inflammation, GI symptoms, ...|
|12-20 breaths/min||4.5-5.5%||20-40 s||Initial stage of the disease||Up to 40-60 years||Mild GI symptoms; slight deterioration in lung function tests|
|< 12 breaths/min||>5.5%||over 40 s 24/7||Normal health||Normal||No symptoms, normal life expectancy|
These Buteyko doctors found that damage to lungs, sinuses, pancreas, liver, intestines, and sex organs in cystic fibrosis is proportional to the degree of respiratory abnormalities, while a complete clinical remission in patients with cystic fibrosis takes place in cases of breathing normalization. Patients with cystic fibrosis have an excellent prognosis and normal life expectancy if they can normalize their breathing pattern. At the same time, low body O2 is one of the central factors of reduced cystic fibrosis life expectancy.
It should be kept in mind that cystic fibrosis affects the lungs and alveoli so that the development of this medical condition leads to increased ventilation-perfusion mismatch and problems with effective gas exchange. Another practical aspect related to cystic fibrosis is that for the overwhelming majority of CF patients, the lowest body oxygenation and heaviest breathing (or worst respiratory parameters) take place during early morning hours (or the last portion of the night sleep) due to the Sleep Heavy Breathing Effect. Obviously, the morning CP (body-oxygen test) is the main parameter that influences prognosis, stages, cystic fibrosis life expectancy and quality of life in CF patients.
This YouTube video is a trailer of the Amazon Kindle Book "Cystic fibrosis: Defeated with Higher Body O2". The book provides details related to application of those methods and techniques, including crucial lifestyle factors, that increase body-O2 content and increases cystic fibrosis life expectancy.
You can find more information and the link to this Amazon Kindle and PDF book "Cystic Fibrosis Life Expectancy: 30, 50, 70..." written by Dr. Artour Rakhimov below.
Kindle Book - Cystic Fibrosis Life Expectancy: 30, 50, 70, ...
Thick mucus is the main culprit in cystic fibrosis. It is caused by the abnormal transport of ions (e.g., Na and Cl) and water across the mucosal layers. This thick mucus starts to harbor pathological bacteria and cause GI and respiratory infections.
However, you probably do not know that the transport of ions and the active transport of water is controlled by O2 levels in cells. If O2 is low, then the transport of chemicals is going to be defective. This effect was found in all people. The CFTR gene just makes the whole picture worse.
Therefore, cystic fibrosis develops when tiny pumps that transport chemicals to form mucus have too little oxygen. If you have normal O2 in cells, you will not develop CF symptoms and problems even if you have the CFTR gene.
It makes common sense that oxygen is the key factor in the active transport of ions and water across epithelial layers. Apart from this, low body O2 suppresses the immune system making respiratory and GI infections much worse.
Therefore, the solution to cystic fibrosis is to restore normal body O2 content 24/7.
You can click on the book image to visit the Amazon Kindle store and get this book now.
The main features of this book:
Cystic Fibrosis Web Pages:
- CFTR mutation gene is triggered by cell hypoxia: Review of medical studies that discovered something that makes common sense: tiny pumps that transport ions across mucosal layers in the respiratory and GI tract require oxygen for their normal work
- Cystic fibrosis symptoms correlate with their parameters of automatic breathing: those who have faster and deeper breathing have less oxygen and worse symptoms
- Cystic fibrosis cause: Each and every study that measured the breathing in people with CF found that they have ineffective breathing, which reduces body O2
- Cystic fibrosis in lungs develops according to laws of physiology and due to effects of hyperventilation
- Cystic fibrosis prognosis depends on one key factor: how the person with CF breathes 24/7
- Cystic fibrosis life expectancy and lung CO2 & body oxygenation
- Therapy For cystic fibrosis: Treatment with breathing retraining
- Cystic fibrosis treatment is currently missing its most important part: techniques that lead to breathing normalization and improved O2 concentrations in body cells.
Reference pages: Breathing norms and medical facts:
- Breathing norms: Parameters, graph, and description of the normal breathing pattern
- 6 breathing myths: Myths and superstitions about breathing and body oxygenation (prevalence: over 90%)
- Hyperventilation: Definitions of hyperventilation: their advantages and weak points
- Hyperventilation syndrome: Western scientific evidence about prevalence of chronic hyperventilation in patients with chronic conditions (37 medical studies)
- Normal minute ventilation: Small and slow breathing at rest is enjoyed by healthy subjects (14 studies)
- Hyperventilation prevalence: Present in over 90% of normal people (24 medical studies)
- HV and hypoxia: How and why deep breathing reduces oxygenation of cells and tissues of all vital organs
- Body-oxygen test (CP test) : How to measure your own breathing and body oxygenation (two in one) using a simple DIY test
- Body oxygen in healthy: Results for the body-oxygen test for healthy people (27 medical studies)
- Body oxygen in sick : Results for the body-oxygen test for sick people (14 medical studies)
- Buteyko Table of Health Zones: Clinical description and ranges for breathing zones: from the critically ill (severely sick) up to super healthy people with maximum possible body oxygenation
- Morning hyperventilation: Why people feel worse and critically ill people are most likely to die during early morning hours
References: pages about CO2 effect:
- Vasodilation: CO2 expands arteries and arterioles facilitating perfusion (or blood supply) to all vital organs
- The Bohr effect: How and why oxygen is released by red blood cells in tissues
- Cell oxygen levels: How alveolar CO2 influences oxygen transport
- Oxygen transport: O2 transport is controlled by vasoconstriction-vasodilation and the Bohr effects, both of which rely on CO2
- Free radical generation: Reactive oxygen species are produced within cells due to anaerobic cell respiration caused by cell hypoxia
- Inflammatory response: Chronic inflammation in fueled by the hypoxia-inducible factor 1, while normal breathing reduces and eliminates inflammation
- Nerve stabilization: People remain calm due to calmative or sedative effects of carbon dioxide in neurons or nerve cells
- Muscle relaxation: Relaxation of muscle cells is normal at high CO2, while hypocapnia causes muscular tension, poor posture and, sometimes, aggression and violence
- Bronchodilation: Dilation of airways (bronchi and bronchioles) is caused by carbon dioxide, and their constriction by hypocapnia (low CO2)
- Blood pH: Regulation of blood pH due to breathing and regulation of other bodily fluids
- CO2: lung damage: Elevated carbon dioxide prevents lung injury and promotes healing of lung tissues
- CO2: Topical carbon dioxide can heal skin and tissues
- Synthesis of glutamine in the brain, CO2 fixation, and other chemical reactions
- Deep breathing myth: Ignorant and naive people promote the idea that deep breathing and breathing more air at rest is beneficial for health
- Breathing control: How is our breathing regulated? Why hypocapnia makes breathing uneven, irregular and erratic.
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