References: Tepper et al, 1983
Tepper RS, Skatrud B, Dempsey JA
Ventilation and oxygenation changes during sleep in cystic fibrosis
Chest 1983; 84; p. 388-393.
Oxygen desaturation during sleep in patients with cystic fibrosis
has been attributed to changes in the end-expiratory volume during rapid eye
movement (REM) sleep, leading to worsening of the ventilation-perfusion
distribution. The purpose of this study was to describe the changes in
ventilation during sleep that may contribute to the oxygen desaturation. Six
adolescent males with moderate to severe cystic fibrosis were studied. It was
concluded that hypoventilation during REM may contribute to oxygen desaturation
in patients with cystic fibrosis.