References: Radwan et al, 1995

Radwan L, Maszczyk Z, Koziorowski A, Koziej M, Cieslicki J, Sliwinski P, Zielinski J

Control of breathing in obstructive sleep apnea and in patients with the overlap syndrome,
Eur Respir J. 1995 Apr; 8(4): p.542-545.

Lung Function Laboratory, Institute of Tuberculosis and Lung Diseases, Warszawa, Poland

In some patients obstructive sleep apnea (OSA) may co-exist with chronic obstructive pulmonary disease (COPD) and respiratory failure; the so-called "overlap syndrome". Obstructive, hypercapnic patients have both blunted ventilatory and mouth occlusion pressure responses during CO2 stimulation. The purpose of this study was to compare the pattern of breathing and CO2 response between OSA patients and those with the overlap syndrome. Twenty obese men with OSA and normal lung function (Group A), 11 obese men with overlap syndrome (Group B) and 13 healthy nonobese subjects (Group C) were examined.

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